Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens guanidinoacetate N-methyltransferase (GAMT), transcript variant 2 (NM_138924). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q14353 |
| Entry Name | GAMT_HUMAN |
| Gene Names | GAMT |
| Alternative Gene Names | |
| Alternative Protein Names | Guanidinoacetate N-methyltransferase (EC 2.1.1.2) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 236 |
| Molecular Weight(Da) | 26318 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG |
Background
| Function | FUNCTION: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512). Important in nervous system development (PubMed:24415674). {ECO:0000269|PubMed:24415674, ECO:0000269|PubMed:26003046, ECO:0000269|PubMed:26319512}. |
| Pathway | Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2. |
| Protein Families | Class I-like SAM-binding methyltransferase superfamily, RMT2 methyltransferase family |
| Tissue Specificity | Expressed in liver. {ECO:0000269|PubMed:8651275}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |